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| Name | Authors | Publication | Added | |
|---|---|---|---|---|
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors | Takahashi et al. | Cell | 3 months ago | |
In vivo amelioration of age-associated hallmarks by partial reprogramming | Ocampo et al. | Cell | 2 months ago | |
Reprogramming to recover youthful epigenetic information and restore vision | Lu et al. | Nature | 6 weeks ago | |
In vivo partial reprogramming alters age-associated molecular changes during physiological aging | Browder et al. | Nature Aging | 1 month ago | |
Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice | Cano Macip et al. | Cellular Reprogramming | Just now | |
The long and winding road of reprogramming-induced rejuvenation | Yücel et al. | Nature Communications | Just now | |
Partial reprogramming by cyclical overexpression of Yamanaka factors improves pathological phenotypes of tauopathy mouse model of human Alzheimer's disease | Antón-Fernández et al. | Progress in Neurobiology | Just now | |
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance | Antón-Fernández et al. | Communications Biology | Just now | |
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming | Lu et al. | Cell | Just now | |
Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche | Xu et al. | Nature Aging | Just now | |
Comparative analysis of mouse strains for in vivo induction of reprogramming factors | Picó et al. | Cell Reports | Just now | |
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation | Mitchell et al. | eLife | Just now | |
Chemically induced reprogramming to reverse cellular aging | Yang et al. | Aging | Just now | |
Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects | Kriukov et al. | Aging Cell | Just now | |
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming | Gill et al. | eLife | Just now | |
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming | Chondronasiou et al. | Aging Cell | Just now | |
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells | Sarkar et al. | Nature Communications | Just now | |
Loss of epigenetic information as a cause of mammalian aging | Yang et al. | Cell | Just now | |
Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity | Olova et al. | Aging Cell | Just now | |
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds | Hou et al. | Science | Just now | |
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state | Lapasset et al. | Genes & Development | Just now |
Found 17 recent papers across PubMed and the web on in vivo partial reprogramming.
The cluster covers lifespan extension via AAV-OSK, neuron-targeted reprogramming for memory and Alzheimer's, mesenchymal drift reversal, chemical reprogramming alternatives, and methodological critiques of epigenetic clocks. I've added them to your folder.
The central risks are loss of cell identity (dedifferentiation into pluripotency) and tumorigenesis, which is why the field has largely moved to OSK-only cocktails that drop c-Myc and to tissue-restricted delivery. 12 A further complication is that the epigenetic clocks used to validate "rejuvenation" carry high uncertainty on reprogrammed cells, so safety and efficacy claims often rest on shaky biomarkers. 3
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curl-X POST https://api.anara.com/v1/search \ -H "Authorization: Bearer $ANARA_API_KEY" \ -H "Content-Type: application/json" \ -d '{ "query": "CRISPR off-target detection", "type": "deep", "maxResults": 20, "filters": { "publicationYear": ">=2021", "hasFulltext": true } }'curl-X POST https://api.anara.com/v1/resolve \ -H "Authorization: Bearer $ANARA_API_KEY" \ -H "Content-Type: application/json" \ -d '{ "identifiers": [ "10.1038/s41586-020-2649-2", "arXiv:1706.03762" ], "titles": ["Deep Residual Learning for Image Recognition"] }'“Anara is how we index, search, and summarize our library of scientific literature for clinical study protocols and FDA regulatory filings. We used it heavily for a submission that just went in last week.”
RobertR&D leader, medtech
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ClaraConsultant, life sciences
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AntonPhD student, sociology
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EthanScientist, biotech
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MeganRegulatory specialist, medtech
“Amazing for scientific research, since Anara shows you exactly where it found the information by highlighting it in the paper. I don’t need to trust an AI, since I can just read the text passage in the paper.”
PriyaAcademic researcher
“Anara is how we index, search, and summarize our library of scientific literature for clinical study protocols and FDA regulatory filings. We used it heavily for a submission that just went in last week.”
RobertR&D leader, medtech
“It’s tailored to science and biology, which is why Anara is so powerful. Instead of spending two hours finding papers, it’s very quick and reliable.”
EthanScientist, biotech
“It will tell me when I’m wrong: this is not clear, or this is where you have a gap. A different AI mostly just agrees with me, and that’s not what I’m looking for.”
MeganRegulatory specialist, medtech
“We were commissioned to do a systematic review across thousands of papers on a very short timeline. Anara helped us build a high-throughput workflow.”
ClaraConsultant, life sciences
“I threw in 700 papers I’ve been gathering over the years and started asking questions, and it worked out really well. It found a theme I’d never picked up on myself while reading, and it turned out the papers were littered with it. That was super useful.”
AntonPhD student, sociology
“Amazing for scientific research, since Anara shows you exactly where it found the information by highlighting it in the paper. I don’t need to trust an AI, since I can just read the text passage in the paper.”
PriyaAcademic researcher
“Anara is how we index, search, and summarize our library of scientific literature for clinical study protocols and FDA regulatory filings. We used it heavily for a submission that just went in last week.”
RobertR&D leader, medtech
“It will tell me when I’m wrong: this is not clear, or this is where you have a gap. A different AI mostly just agrees with me, and that’s not what I’m looking for.”
MeganRegulatory specialist, medtech
“We were commissioned to do a systematic review across thousands of papers on a very short timeline. Anara helped us build a high-throughput workflow.”
ClaraConsultant, life sciences
“It’s tailored to science and biology, which is why Anara is so powerful. Instead of spending two hours finding papers, it’s very quick and reliable.”
EthanScientist, biotech
“I threw in 700 papers I’ve been gathering over the years and started asking questions, and it worked out really well. It found a theme I’d never picked up on myself while reading, and it turned out the papers were littered with it. That was super useful.”
AntonPhD student, sociology
“Amazing for scientific research, since Anara shows you exactly where it found the information by highlighting it in the paper. I don’t need to trust an AI, since I can just read the text passage in the paper.”
PriyaAcademic researcher
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